Bithiazole Correctors Rescue CFTR Mutants by Two Different Mechanisms
نویسندگان
چکیده
منابع مشابه
Bithiazole Correctors Rescue CFTR Mutants by Two Different Mechanisms
Better correctors are needed to repair cystic fibrosis transmembrane conductance regulator (CFTR) processing mutants that cause cystic fibrosis. Determining where the correctors bind to CFTR would aid in the development of new correctors. A recent study reported that the second nucleotide-binding domain (NBD2) was involved in binding of bithiazole correctors. Here, we show that bithiazole corre...
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ژورنال
عنوان ژورنال: Biochemistry
سال: 2013
ISSN: 0006-2960,1520-4995
DOI: 10.1021/bi4008758